Immune Cell Signaling Discovery Could Help Autoimmune Disease Treatment – Technology Networks

We’ve updated our Privacy Policy to make it clearer how we use your personal data.
We use cookies to provide you with a better experience. You can read our Cookie Policy here.
Complete the form below and we will email you a PDF version of “Immune Cell Signaling Discovery Could Help Autoimmune Disease Treatment”
Autoimmune diseases are triggered when the immune system malfunctions and attacks the body’s own structures. Although there is not, as yet, any cure for such diseases, their progression can be slowed down by therapeutic measures. Researchers at MedUni Vienna’s Center for Physiology and Pharmacology have now discovered a central signaling pathway in immune cells that may help in the development of a new therapeutic approach. Their study was recently published in the journal Cell Reports.

The immune system protects the body from infections of all kinds and is designed to distinguish between foreign threats and the body’s own tissues. T cells, which are deployed at the command of other immune cells, the dendritic cells, are an important component of the immune system. The dendritic cells are not only responsible for activating the T cells but also for deactivating them – primarily to prevent them from attacking the body’s own tissues. This mechanism, known as immunotolerance, is the key to the current treatments for autoimmune diseases, whereby certain pharmaceutical agents (JAK inhibitors) are used. The aim is to inhibit T-cell activity against endogenous structures, so as to slow down the progression of the autoimmune disease.

JAK inhibitors are used to treat various autoimmune diseases, such as rheumatoid arthritis. The effect of the inhibitors – on all immune cells simultaneously – has been demonstrated in several studies. A research team led by Gernot Schabbauer and Omar Sharif from the Institute of Vascular Biology and Thrombosis Research at MedUni Vienna’s Center for Physiology and Pharmacology has now investigated the specific effect of JAK inhibitors on dendritic cells and, in particular, the role played by the immunotolerance of T cells (peripheral T cell tolerogenesis) in autoimmune diseases.

Working in collaboration with scientists at the Christian Doppler Laboratory for Arginine Metabolism in Rheumatoid Arthritis and Multiple Sclerosis at MedUni Vienna and St. Anna Children’s Cancer Research, they discovered a key building block in immune cells that is relevant in the context of autoimmune diseases. “This is the signaling pathway in dendritic cells that promotes T-cell tolerogenesis. This enables the dendritic cells to increase the immunotolerance of the T cells in particular and prevent them from attacking the body’s own structures,” explains the study’s lead author Andrea Vogel from MedUni Vienna’s Institute of Vascular Biology and Thrombosis Research.

The researchers’ findings are a step towards a potential new cell-based therapeutic approach for autoimmune diseases. The aim is to specifically target the signaling pathway in the dendritic cells, so as to “switch off” the misdirected T cells and slow down progression of the autoimmune disease. Further research on this will follow, emphasises Andrea Vogel: “The next thing we want to investigate is whether this signaling pathway in dendritic cells also plays a role in cancer.”

Reference: Vogel A, Martin K, Soukup K, et al. JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction. Cell Rep. 2022;38(8). doi:10.1016/j.celrep.2022.110420

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

source

Share:

More Posts

Market Research

Pulse Surveys

Turn feedback into action

Our survey platform makes it easy to measure and understand feedback so you can drive growth and innovation

Pulse Handshak

Pulse Handshak

Collaborative online survey tool for the market research industry. Remote assisted surveying just like face-to-face interviews. Here interviewers can talk to the respondent over the web-console without the need for any other communication channel and share the same Q're with responses and click actions.

Pulse FE

Pulse FE

Pulse Field Expert or Pulse FE is the main platform for both offline and online survey at softofficepro.com. It is robust and used by hundreds of clients over tens of years with millions of responses. Do it once Q're and deploy on both offline devices (android) and online forms makes it a great cost effective platform for any kind of responses

Pulse Ultimate

Pulse Ultimate

Pulse Ultimate is targeted for tracking studies and retail audits. An offline survey system offering extreme field control including processes like data quality check, back-check, rework, comparison with previous wave data etc. helps to get the best results on a day-to-day basis

Pulse LS

Pulse LS

Use a managed Limesurvey and our expertise for creating complex forms and token based user management. Use optional mailing system to send survey invitation to each participant and track progress of the response status. Industry standard SPSS / R output supported