Discovery of a New Gene That Drives Heart Muscle Cell Degradation – Technology Networks

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Researchers from the group of Eva van Rooij used advanced sequencing technology to better understand the heart disease arrhythmogenic cardiomyopathy, in which heart muscle tissue is replaced by fat cells. Using explanted human hearts, they found regions in which heart muscle was actively degenerated and identified a new gene, ZBTB11, that drives heart muscle cell degradation. The results were published in Cardiovascular Research on 17 May 2022.

Arrhythmogenic cardiomyopathy (ACM) is a familial heart disease in which heart muscle tissue is replaced by fat cells. It can lead to life threatening, irregular heartbeats. Currently, no therapy exists to cure arrhythmogenic cardiomyopathy and patients may ultimately need a heart transplantation. Therefore, the group of Eva van Rooij at the Hubrecht Institute collaborated with the UMC Utrecht with the aim to better understand the process of heart muscle degeneration in ACM, to ultimately contribute to the identification of new therapeutic targets to treat the disease.



Reference: Boogerd CJ, Lacraz GPA, Vértesy Á, et al. Spatial transcriptomics unveils ZBTB11 as a regulator of cardiomyocyte degeneration in arrhythmogenic cardiomyopathy. Cardiovasc. Res. 2022:cvac072. doi: 10.1093/cvr/cvac072

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