Cellular Process Could Reveal Insights Into Aging-Related Diseases – Technology Networks

We’ve updated our Privacy Policy to make it clearer how we use your personal data.
We use cookies to provide you with a better experience. You can read our Cookie Policy here.
Complete the form below and we will email you a PDF version of “Cellular Process Could Reveal Insights Into Aging-Related Diseases”
The study of autophagy – the recycling and repair process within cells – has huge potential to aid in fighting the ageing process, bacterial and viral infections and diseases including cancer, Alzheimer’s and Parkinson’s.

A team of researchers led by Professor Ioannis Nezis from the School of Life Sciences at the  University of Warwick, has identified the molecular and cellular mechanisms that regulate selective autophagy in the fruit fly Drosophila melanogaster.


While the function of these processes is increasingly understood in mammals this is one of the first studies in insects.

The study opens new avenues in our understanding of the regulation of Golgi complex turnover by selective autophagy. The Golgi complex is a stack of flat sacs formed by membranes inside the cell. It prepares proteins and fat molecules for transportation and use in other places inside and outside the cell.

Professor Nezis and his team used gene editing, confocal and electron microscopy to identify a novel type of selective autophagy, termed Golgiphagy, meaning how cells degrade a cell organelle called Golgi complex by autophagy.

In the paper, ‘GMAP is an Atg8a-inteacting protein that regulates Golgi turnover in Drosophila’ published today [31] in the journal Cell Reports, PhD students Ashrafur Rahman, Raksha Gohel and colleagues describe how gene editing was used to create fruit flies unable to process specific proteins by autophagy.

Comparison of the gene edited flies with their wild type counterparts showed:-
 
Lead author of the research Professor Ioannis Nezis from the School of Life Sciences at the University of Warwick, said:

“Understanding the molecular mechanisms of selective autophagy of Golgi complex in cells will help open new avenues of research that will assist elucidating the underlying cellular mechanisms of diseases.”


Reference: Rahman A, Lőrincz P, Gohel R, et al. GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila. Cell Rep. 2022;39(9). doi: 10.1016/j.celrep.2022.110903

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

source

Share:

More Posts

Market Research

Pulse Surveys

Turn feedback into action

Our survey platform makes it easy to measure and understand feedback so you can drive growth and innovation

Pulse Handshak

Pulse Handshak

Collaborative online survey tool for the market research industry. Remote assisted surveying just like face-to-face interviews. Here interviewers can talk to the respondent over the web-console without the need for any other communication channel and share the same Q're with responses and click actions.

Pulse FE

Pulse FE

Pulse Field Expert or Pulse FE is the main platform for both offline and online survey at softofficepro.com. It is robust and used by hundreds of clients over tens of years with millions of responses. Do it once Q're and deploy on both offline devices (android) and online forms makes it a great cost effective platform for any kind of responses

Pulse Ultimate

Pulse Ultimate

Pulse Ultimate is targeted for tracking studies and retail audits. An offline survey system offering extreme field control including processes like data quality check, back-check, rework, comparison with previous wave data etc. helps to get the best results on a day-to-day basis

Pulse LS

Pulse LS

Use a managed Limesurvey and our expertise for creating complex forms and token based user management. Use optional mailing system to send survey invitation to each participant and track progress of the response status. Industry standard SPSS / R output supported